Colloquium: Virtual Tissue Computer Simulations of Toxicity and Developmental Diseases
Virtual Tissue Computer Simulations of Toxicity and Developmental Diseases
Prof. James A. Glazier, Biocomplexity Institute and Department of Intelligent Systems Engineering, Indiana University Bloomington
The difficulty of predicting the emergent development, homeostasis and disfunction of tissues from cells’ molecular signatures limits our ability to integrate molecular and genetic information to make meaningful predictions at the organ or organism level. Virtual Tissues are an approach to constructing quantitative, predictive mechanistic models starting from cell behaviors and combining subcellular molecular kinetics models, the physical and mechanical behaviors of cells and the longer range effects of the extracellular environment. For the past 15 years, we have been developing Virtual-Tissue tools (CompuCell3D) to bridge the gap between molecule and physiological outcome. I will illustrate these approaches in: 1) the maintenance of blood vessels and its role in Diabetic Retinopathy and its treatment, 2) the disorganization of normal tubular structure which occurs in Polycystic Kidney Disease, which leads to overgrowth and eventual kidney failure, and 3) toxin-induced damage in the liver. I will also discuss the types of questions that Virtual Tissue simulations can address and the types of experimental data required for their development and validation.
Description: Glazier_PhotoDr. Glazier received his B.A. in Physics and Mathematics from Harvard University and his M.S. and Ph.D. in Physics from the University of Chicago. His research focuses on experimental and computational approaches to pattern formation in embryology. He has held faculty appointments at the University of Notre Dame and Indiana University, Bloomington, where he is founding director of the Biocomplexity Institute, Professor of Intelligent Systems Engineering and Adjunct Professor of Physics, Informatics and Biology.